| Background: The skeletal muscle toxicity that accompanies the chemotherapy drug doxorubicin (DOX) may lead to cancer patient weakness and fatigue. This myotoxicity involves myogenic regulatory factor (MRF) disruption which alters muscle integrity and regeneration. Endurance exercise enhances MRF expression and thereby may mitigate DOX-induced MRF disruptions. This study examined the effects of endurance training and DOX treatment on myogenic regulatory factor (MRF) expression. Methods: Male rats were exercise trained (EXER) or remained sedentary (SED) for two weeks. EXER and SED then received either DOX (15 mg/kg) or saline (SAL). Soleus, extensor digitorum longus (EDL), and diaphragm were excised 24 hours post injection, and MRF expression was analyzed. Results: Significant Myf5 drug and activity effects were observed in the soleus with EXER+DOX expressing higher Myf5 than SED+DOX. A significant drug effect was detected in soleus MyoD, and a significant activity effect was detected in soleus Mrf4. No main effects or interactions were observed in the EDL, but in the diaphragm, a significant activity effect was observed for Myf5 with EXER+DOX expressing higher levels than SED+DOX. Conclusion: Doxorubicin treatment increased soleus MRFs and exercise boosted MRF response in soleus and diaphragm suggesting that exercise may enhance regenerative signaling with DOX treatment. Level of evidence: I b, individual randomized controlled trial |
Effects of endurance exercise and doxorubicin on skeletal muscle myogenic regulatory factor expression
Quinn C.J., Hydock D.S.
Original Article, 418 - 425
Keywords: anthracycline, diaphragm, fast muscle, slow muscle.,
Table of Content: Vol. 7 (No. 3) 2017 July/September
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“I performed experiments and I have results. Wow, and now?”
Padulo J., De Giorgio A., Oliva F., Frizziero A., Maffulli N.Editorial, 403 - 410 -
Spheroid formation and modulation of tenocyte-specific gene expression under simulated microgravity
Kraus A., Luetzenberg R., Abuagela N., Hollenberg S., Infanger M.Original Article, 411 - 417 -
Effects of endurance exercise and doxorubicin on skeletal muscle myogenic regulatory factor expression
Quinn C.J., Hydock D.S.Original Article, 418 - 425 -
The effect of intra-articular allogenic platelet rich plasma in Dunkin-Hartley guinea pig model of knee osteoarthritis
Kanwat H., Mandeep Singh D., Devendra Kumar C., Alka B., Biman S., Aman H.Original Article, 426 - 434 -
The time has come to incorporate a greater focus on rate of force development training in the sports injury rehabilitation process
Buckthorpe M., Roi G.S.Review Article, 435 - 441 -
Three-dimensional architecture of the ligamentum teres in the human hip joint
Kaku N., Shimada T., Tabata T., Tagomori H., Abe T., Zhang J.J., Tsumura H.Original Article, 442 - 448 -
Quantitative analysis of patellar tendon size and structure in asymptomatic professional players: sonographic study
Giacchino M., Caresio C., Gorji N.E., Molinari F., Massazza G., Minetto M.A.Original Article, 449 - 458 -
Prevalence, techniques and knowledge of rapid weight loss amongst adult british judo athletes: a questionnaire based study
Malliaropoulos N., Rachid S., Korakakis V., Fraser F.A., Bikos G., Maffulli N., Angioi M.Original Article, 459 - 466 -
“Real-time sonoelastography: principles and clinical applications in tendon disorders. A systematic review”
Fusini F., Langella F., Busilacchi A., Tudisco C., Gigante A., Massé A., Bisicchia S.Original Article, 467 - 477 -
MRI evaluation to predict tendon size for knee ligament reconstruction
Camarda L., Grassedonio E., Albano D., Galia M., Midiri M., D'Arienzo M.Original Article, 478 - 484 -
Ultrasonographic assessment of the anterolateral ligament of the knee in healthy subjects
Argento G., Vetrano M., Cristiano L., Suarez T., Bartoloni A., Erroi D., Ferretti A., Vulpiani M.C.Original Article, 485 - 490 -
“Correlation between time from injury to surgery and the prevalence of ramp and hidden lesions during anterior cruciate ligament reconstruction. A new diagnostic algorithm”
Di Vico G., Di Donato S.L., Balato G., Correra G., D'Addona A., Maffulli N., Rosa D.Original Article, 491 - 497 -
Evaluation of the isokinetic muscle function, postural control and plantar pressure distribution in capoeira players: a cross-sectional study
de Paula Lima P.O., Pinto Camelo P.R., Mascarenhas Ferreira V.M.L., do Nascimento P.J.S., Almeida Bezerra M., Almeida G.P.L., de Oliveira R.R.Original Article, 498 - 503 -
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Castorina S., Guglielmino C., Castrogiovanni P., Szychlinska M.A., Ioppolo F., Massimino P., Leonardi P., Maci C., Iannuzzi C., Di Giunta A., Musumeci G.Original Article, 504 - 513 -
Assessment of patient functional performance in different knee arthroplasty designs during unconstrained squat
Verdini F., Zara C., Leo T., Mengarelli A., Cardarelli S., Innocenti B.Original Article, -
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Gonçalves Arliani G., Schmidt Lara P.H., Costa Astur D., Pedrinelli A., Pagura J.R., Cohen M.Original Article, 524 - 531 -
Early radiographic and clinical outcomes of minimally displaced proximal fifth metatarsal fractures: cast vs functional bandage
Biz C., Zamperetti M., Gasparella A., Dalmau-Pastor M., Corradin M., de Guttry G., Ruggieri P.Original Article, 532 - 540 -
Side-to-side differences in Achilles tendon geometry and mechanical properties following achilles tendon rupture
Zellers J.A., Cortes D.H., Corrigan P., Pontiggia L., Silbernagel K.G.Original Article, 541 - 547 -
The effect of strain and age on the mechanical properties of rat Achilles tendons
Vafek E.C., Plate J.F., Friedman E., Mannava S., Scott A.T., Danelson K.A.Original Article, 548 - 553 -
Mini open versus open repair techniques in Achilles tendon rupture: clinical and isokinetic evaluation
Munegato D., Gridavilla G., Guerrasio S., Turati M., Cazzaniga C., Zanchi N., Zatti G., Bigoni M.Original Article, 554 - 561 -
Congenital absence of the long head of biceps tendon & its clinical implications: a systematic review of the literature
Devendra Kumar C., Rakesh J., Tungish B., Mandeep Singh D.Review Article, 562 - 569 -
Operative treatment for the painful posterior thigh after hamstring autograft harvesting
Laakso M., Kosola J., Niemi P., Mäkelä K., Ranne J., Orava S., Lempainen L.Original Article, 570 - 575 -
Time to recovery of sciatic function index after induced tibialis anterior strain in rats
Mohammad T., Youssef A.R.Original Article, 576 - 582 -
Sciatic nerve stiffness is not changed immediately after a slump neurodynamics technique
Neto T., Freitas S.R., Andrede R.J., Gomes J., Vaz J., Mendes B., Firmino T., Nordez A., Oliveira R.Original Article, 583 - 589