Introduction: High failure rates have been reported for rotator cuff repairs. Tendon grafts have been developed to augment these repairs. Two types of grafts are collagen sponge and collagen fibres. This study investigates the biocompatibility of a biphasic collagen sponge as a bone-tendon interposition device that may induce tendon regeneration, comparing its results to an established tendon graft.
Methods: Ovine tenocytes were exposed to either: (1) Control – a collagen fibre that has been shown to be conducive to tenocytes; (2) intervention – Chondromimetic, a novel biphasic tendon sponge, consisting of mineralized and unmineralized layers.
The following parameters were measured over a three week period: cellular DNA, type I collagen, decorin, and glycosaminoglycan production.
Results: Tendon cells are able to adhere and multiply in the collagen sponge. The increase in cellular DNA, type I collagen, and glycosaminoglycan in the collagen sponge graft was similar to fibre graft over the study period.
Conclusion: Chondromimetic is biocompatible with ovine tendon cell growth.
Level of evidence: IIIb