| We evaluated whether matrix metalloproteases and their inhibitors are involved in extracellular matrix remodelling and degradation of chronic rotator cuff tears. Tendon samples were harvested from 13 patients who underwent arthroscopic repair of a rotator cuff tear. Supraspinatus specimens were harvested en bloc from the arthroscopically intact middle portion of the tendon, more than 1 cm lateral to the torn edge, from the lateral edge of the tear, and from the superior margin of the macroscopically intact subscapularis tendon, used as control. The collagenases, the stromelysins, and the tissue inhibitors of metalloprotease arrays were analyzed blindly by multiplex sandwich ELISA in each specimen. Histological evidence of tendinopathy was present in all patients with a rotator cuff tear, but not in the macroscopically intact subscapularis tendon. There were significantly increased levels of MMP 1, MMP 2, MMP 3, TIMP-1, and TIMP-2 in all specimens examined, including the macroscopically intact portion of the supraspinatus tendon and the subscapularis (control specimens). The levels of specific matrix metalloproteases and their inhibitors are altered in torn rotator cuff tendons, but also in the macroscopically and histologically intact tendons. These changes extended medially to the site of tendon tear, and to other tendons |
Matrix metalloproteases and their inhibitors are altered in torn rotator cuff tendons, but also in the macroscopically and histologically intact portion of those tendons
Castagna A., Cesari E., Garofalo R., Gigante A., Conti M., Markopoulos N., Maffulli N.
Original Article, 132 - 138
Keywords: gene expression, outcome., rotator cuff, surgery.,
Table of Content: Vol. 3 (No. 3) 2013 July/September
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Sample size determination for clinical research
Wang D., Bakhai A., Del Buono A., Maffulli N.Original Article, 116 - 117 -
Tendon cell ciliary length as a biomarker of in situ cytoskeletal tensional homeostasis
Lavagnino M., Gardner K., Sedlak A.M., Arnoczky S.POriginal Article, 118 - 121 -
New insights in extracellular matrix remodeling and collagen turnover related pathways in cultured human tenocytes after ciprofloxacin administration
Menon A., Pettinari L., Martinelli C., Colombo G., Portinaro N., Delle-Donne I., D'Agostino M.C., Gagliano N.Original Article, 122 - 131 -
Matrix metalloproteases and their inhibitors are altered in torn rotator cuff tendons, but also in the macroscopically and histologically intact portion of those tendons
Castagna A., Cesari E., Garofalo R., Gigante A., Conti M., Markopoulos N., Maffulli N.Original Article, 132 - 138 -
Augmenting tendon and ligament repair with platelet-rich plasma (PRP)
Yuan T., Zhang C-Q, WangOriginal Article, 139 - 149 -
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Maffulli N., Margiotti K., Longo U.G., Loppini M., Fazio V.M., Denaro V.Review Article, 179 - 189 -
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Impingement is not impingement: the case for calling it “Rotator Cuff Disease”
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