| Tendons are often subject to age related degenerative changes that coincide with a diminished regenerative capacity. Torn tendons often heal by forming scar tissue that is structurally weaker than healthy native tendon tissue, predisposing to mechanical failure. There is increasing interest in providing biological stimuli to increase the tendon reparative response. Stem cells in particular are an exciting and promising prospect as they have the potential to provide appropriate cellular signals to encourage neotendon formation during repair rather than scar tissue. Currently, a number of issues need to be investigated further before it can be determined whether stem cells are an effective and safe therapeutic option for encouraging tendon repair. This review explores the in-vitro and invivo evidence assessing the effect of stem cells on tendon healing, as well as the potential clinical applications. |
Mesenchymal stem cell applications to tendon healing
Chaudhury S.
Review Article, 222 - 229
Keywords: cytokines, regeneration, rotator cuff, stem cell, tendon,
Table of Content: Vol. 2 (No. 3) 2012 July/September
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Stem cells for soft injuries
Berardi A. C., Oliva F.Editorial, 153 -
Tendon stem cells: experimental and clinical perspectives in tendon and tendon-bone junction repair
Po Yee Lui P., Wong O.T.Review Article, 163 - 168 -
Mesenchymal stem cell responses to mechanical stimuli
Delaine-Smith R.M., Reilly G.C.Review Article, 169 - 180 -
Stem cell therapy of tendinopathies: suggestions from veterinary medicine
Muttini A., Salini V., Valbonetti L., Abate M.Review Article, 187 - 192 -
Stem cell research and clinical development in tendon repair
Filomeno P., Dayan V., Tourino C.Review Article, 204 - 211 -
The role of microvesicles derived from mesenchymal stem cells in tissue regeneration; a dream for tendon repair?
Tetta C., Consiglio A.L., Bruno S., Tetta E., Gatti E., Dobreva M., Cremonesi F., Camussi G.Review Article, 212 - 221 -
Mesenchymal stem cell applications to tendon healing
Chaudhury S.Review Article, 222 - 229 -
Tissue engineering for skeletal muscle regeneration
Rizzi R., Bearzi C., Mauretti A., Bernardini S., Cannata S., Gargioli C.Review Article, 230 - 234 -
Stem cells and tendinopathy: state of the art from the basic science to clinic application
Ruzzini L., Longo U.G., Rizziello G., Denaro V.Mini-Review, 235 - 238 -
Mesenchymal stem cells, aging and regenerative medicine
Raggi C., Berardi A. C.Mini-Review, 239 - 242