Metalloproteases and tendinopathy

Del Buono A., Oliva F., Osti L., Maffulli N.
Review Article, 51 - 57
doi: 10.11138/mltj/2013.3.1.051
Full text PDF
Matrix metalloproteinases (MMP) are involved in the development of tendinopathy. These potent enzymes completely degrade all components of the connective tissue, modify the extracellular matrix (ECM), and mediate the development of painful tendinopathy. To control the local activity of activated proteinases, the same cells produce tissue inhibitors of metalloproteinases (TIMP). These latter bind to the enzyme and prevent degradation. The balance between the activities of MMPs and TIMPs regulates tendon remodeling, whereas an imbalance produces a collagen dis-regulation and disturbances in tendons. ADAMs (a disintegrin and metalloproteinase) are cell membrane-linked enzymes with proteolytic and cell signaling functions.
ADAMTSs (ADAM with thrombospondin motifs) are secreted into the circulation and constitute a heterogenous family of proteases with both anabolic and catabolic functions. Further studies
are needed to better define the mechanism of action, and whether these new strategies are safe and effective in larger models.
Keywords: metalloproteases, tendinopathy, tendon healing,

Table of Content: Vol. 3 (No. 1) 2013 January/March

  1. Tendon’s ultrastructure

    Tresoldi I., Oliva F., Benvenuto M., Fantini M., Masuelli L., Bei R., Modesti A.
    Original Article, 2 - 6
    doi: 10.11138/mltj/2013.3.1.002
    Full text PDF

  2. Relationship between compressive loading and ECM changes in tendons

    Docking S., Samiric T., Scase E., Purdam C., Cook J.
    Original Article, 7 - 11
    doi: 10.11138/mltj/2013.3.1.007
    Full text PDF

  3. Specialisation of extracellular matrix for function in tendons and ligaments

    Birch H.L., Thorpe C.T., Rumian A.P.
    Review Article, 12 - 22
    doi: 10.11138/mltj/2013.3.1.012
    Full text PDF

  4. Nanomechanics of collagen microfibrils

    Vesentini S., Redaelli A., Gautieri A.
    Original Article, 23 - 24
    doi: 10.11138/mltj/2013.3.1.023
    Full text PDF

  5. Muscle extracellular matrix degradation and contractibility following tendon rupture and disuse

    Zhang Q., Joshi S.K., Manzano G., Lovett D.H., Kim H.T., Liu X.
    Original Article, 35 - 41
    doi: 10.11138/mltj/2013.3.1.035
    Full text PDF

  6. Tendon structure and extracellular matrix components are affected by spasticity in cerebral palsy patients

    Gagliano N., Menon A., Martinelli C., Pettinari L., Panou A., Milzani A., Dalle-Donne I., Portinaro N.M.
    Original Article, 42 - 50
    doi: 10.11138/mltj/2013.3.1.042
    Full text PDF

  7. Metalloproteases and tendinopathy

    Del Buono A., Oliva F., Osti L., Maffulli N.
    Review Article, 51 - 57
    doi: 10.11138/mltj/2013.3.1.051
    Full text PDF