|Matrix metalloproteinases (MMP) are involved in the development of tendinopathy. These potent enzymes completely degrade all components of the connective tissue, modify the extracellular matrix (ECM), and mediate the development of painful tendinopathy. To control the local activity of activated proteinases, the same cells produce tissue inhibitors of metalloproteinases (TIMP). These latter bind to the enzyme and prevent degradation. The balance between the activities of MMPs and TIMPs regulates tendon remodeling, whereas an imbalance produces a collagen dis-regulation and disturbances in tendons. ADAMs (a disintegrin and metalloproteinase) are cell membrane-linked enzymes with proteolytic and cell signaling functions.
ADAMTSs (ADAM with thrombospondin motifs) are secreted into the circulation and constitute a heterogenous family of proteases with both anabolic and catabolic functions. Further studies
are needed to better define the mechanism of action, and whether these new strategies are safe and effective in larger models.
Metalloproteases and tendinopathy
Del Buono A., Oliva F., Osti L., Maffulli N.
Review Article, 51 - 57
Keywords: metalloproteases, tendinopathy, tendon healing,
Table of Content: Vol. 3 (No. 1) 2013 January/March
Tendon’s ultrastructureTresoldi I., Oliva F., Benvenuto M., Fantini M., Masuelli L., Bei R., Modesti A.Original Article, 2 - 6
Relationship between compressive loading and ECM changes in tendonsDocking S., Samiric T., Scase E., Purdam C., Cook J.Original Article, 7 - 11
Specialisation of extracellular matrix for function in tendons and ligamentsBirch H.L., Thorpe C.T., Rumian A.P.Review Article, 12 - 22
Nanomechanics of collagen microfibrilsVesentini S., Redaelli A., Gautieri A.Original Article, 23 - 24
Muscle extracellular matrix degradation and contractibility following tendon rupture and disuseZhang Q., Joshi S.K., Manzano G., Lovett D.H., Kim H.T., Liu X.Original Article, 35 - 41
Tendon structure and extracellular matrix components are affected by spasticity in cerebral palsy patientsGagliano N., Menon A., Martinelli C., Pettinari L., Panou A., Milzani A., Dalle-Donne I., Portinaro N.M.Original Article, 42 - 50
Metalloproteases and tendinopathyDel Buono A., Oliva F., Osti L., Maffulli N.Review Article, 51 - 57