| Low-level oxidative stress induces an adaptive response commonly defined as hormesis; this type of stress is often related to reactive oxygen species (ROS) originating from the mitochondrial respiratory chain (mitochondrial hormesis or mitohormesis). The accumulation of transient low doses of ROS either through chronic physical activity or caloric restriction influences signaling from the mitochondrial compartment to the cell, reduces glucose metabolism, induces mitochondrial metabolism, increases stress resistance and ultimately, increases lifespan. Mitochondrial formation of presumably harmful levels (chronic and/or excessive) of ROS within skeletal muscle has been observed in insulin resistance of obese subjects, type 2 diabetes mellitus, as well as in impaired muscle function associated with normal aging. Advances in mitochondrial bioimaging combined with mitochondrial biochemistry and proteome research have broadened our knowledge of specific cellular signaling and other related functions of the mitochondrial behavior. In this review, we describe mitochondrial remodeling in response to different degrees of oxidative insults induced in vitro in myocytes and in vivo in skeletal muscle, focusing on the potential application of a combined morphological and biochemical approach. The use of such technologies could yield benefits for our overall understanding of physiology for biotechnological research related to drug design, physical activity prescription and significant lifestyle changes. |
Mitohormesis in muscle cells: a morphological, molecular, and proteomic approach
Berbieri E., Sestili P., Vallorani L., Guescini M., Calcabrini C., Gioacchini A.M., Annibalini G., Lucertini F., Piccoli G., Stocchi V.
Review, 254 - 266
Keywords: hormesis., mitochondria, ROS, skeletal muscle,
Table of Content: Vol. 3 (No. 4) 2013 October/December
-
ISMuLT skeletal muscles injuries Guidelines
Maffulli N., Nanni G.Editorial, 240 -
ISMuLT Guidelines for muscle injuries
Maffulli N., Oliva F., Frizziero A., Nanni G., Barazzuol M., Giai Via A., Ramponi C., Brancaccio P., Lisitano G., Rizzo D., Freschi M., Galletti S., Melegati G., Pasta G., Testa V., Valent A., Del Buono A.Guidelines, 241 - 249 -
Muscle, Ligaments and Tendons Journal. Basic principles and recommendations in clinical and field science research
Padulo J., Oliva F., Frizziero A., Maffulli N.Technical Note, 250 - 252 -
Mitohormesis in muscle cells: a morphological, molecular, and proteomic approach
Berbieri E., Sestili P., Vallorani L., Guescini M., Calcabrini C., Gioacchini A.M., Annibalini G., Lucertini F., Piccoli G., Stocchi V.Review, 254 - 266 -
Morphogenesis of rat myotendinous junction
Curzi D., Ambrogini P., Falcieri E., Burattini S.Original Article, 275 - 280 -
Surgical repair of muscle laceration: biomechanical properties at 6 years follow-up
Oliva F., Giai Via A., Kiritsi O., Foti C., Maffulli N.Original Article, 313 - 317 -
The acute effect of the tongue position in the mouth on knee isokinetic test performance: a highly surprising pilot study
di Vico R., Ardigò L. P., Salernitano G., Chamari K., Padulo J.Original Article, 318 - 323 -
Reducing muscle injuries and reinjuries in one italian professional male soccer team
Melegati G., Tornese D., Trabattoni A., Gevi M., Pozzi G., Schonhuber H., Volpi P.Original Article, 324 - 330 -
Thigh muscles injuries in professional soccer players: a one year longitudinal study
Corazza A., Orlandi D., Baldari A., Gatto P., Stellatelli M., Mazzola C., Galli R., Longo S., Sconfienza L.M., Silvestri E.Original Article, 331 - 336 -
Regeneration of injured skeletal muscle after the injury
Järvinen T. AH, Järvinen M., Kalimo H.Review, 337 - 345 -
Insight in spastic musculoskeletal structures in cerebral palsy: impaired or compensatory structural changes?
Di Lorenzo L., Forte A.M., Forte F.Letter to the Editor, 356 - 358 -
My experience from ECOSEP Bauerfeind Travelling Fellowship 2013
Nikos M., Valle X., Tsapralis K., Lohrer H., Padhiar N., Maffulli N.Letter to the Editor, 358