| Background: nutraceuticals are common support therapy for management of tendinopathies. Even if they are widely diffused, our knowledge is still poor. The aim of this systematic review is to analyze the most commonly used nutraceuticals and their effects on tendons. Methods: glucosamine and chondroitin sulphate, vitamin C, hydrolazed type 1 collagen, arginine alpha-keto-glutarate, bromelain, curcumin, boswellic acid, and methil-sulfonil-methane were considered. During the last week of Dicember 2015 a comprehensive research of main databases for each substance was made in relation with tendinopathy. Repeated articles, articles not in English nor in Italian, not common nutraceuticals, and articles not related with tendons or tenocytes were excluded. Clinical article quality was assessed independently by two reviewers using the modified Coleman methodology score. Results: preclinical and clinical data from 46 articles from all databases were analyzed. All these nutraceuticals demonstrated several effects on normal and pathological tendons. Preclinical and clinical studies showed a possible role on collagen synthesis, inflammation, mechanical properties, and maturation of collagen bundles, antioxidant effect, edema, and analgesia. The majority clinical studies had some methodological limitations with an average Modified Coleman Methodology Score of 51.3 points and SD of 20.5 points. In particular, there were very low values in power, error, outcome assessment, and clinical effect. Conclusion: preclinical results are very encouraging, however they are not fully confirmed by clinical studies. There are few clinical papers on the use of nutraceuticals in tendon disorders, and their methodological quality is poor. Furthermore, in most of the studies more than one supplement was administered at the same time. This may bias the results, and the effect of each single component cannot be determined. Furthermore, the interactions between nutraceuticals and drugs, or other dietary supplements (especially at high doses) has not been evaluated, neither their effects on chronic diseases. For these reasons, it is not possible to draw any definitive raccomendations on the use of nutraceutical supplementation in tendinopathies. |
Nutraceutical supplement in the management of tendinopathies: a systematic review
Fusini F., Bisicchia S., Bottegoni C., Gigante A., Zanchini F., Busilacchi A.
Review Article, 48 - 57
Keywords: arginine alpha-keto-glutarate, ascorbate, boswellic acid, curcumin, oral supplement, tendon disorder.,
Table of Content: Vol. 6 (No. 1) 2016 January/March
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Pseudoaneurysm of peroneal artery after ankle Arthroscopy
Errata Corrige, 0 -
Muscles, Ligaments and Tendons Journal – Basic principles and recommendations in clinical and field Science Research: 2016 Update
Padulo J., Oliva F., Frizziero A., Maffulli N.Technical Note, 1 - 5 -
Investigating the cellular origin of rotator cuff muscle fatty infiltration and fibrosis after injury
Original Article, 6 - 15 -
Evidence of healing of partial-thickness rotator cuff tears following arthroscopic augmentation with a collagen implant: a 2-year MRI follow-up
Bokor D.J., Sonnabend D., Deady L., Cass B., Young A., Van Kampen C., Arnoczky S.Original Article, 16 - 25 -
Adhesive capsulitis of the shoulder and diabetes: a meta-analysis of prevalence
Hani Zreik N., Malik R.A., Charalambous C.P.Review Article, 26 - 34 -
Initial treatment of complete rotator cuff tear and transition to surgical treatment: systematic review of the evidence
Abdul-Wahab T.A., Betancourt J.P., Hassan F., Al. Thani4 S., Choueiri H., Jain N.B., Malanga G.A., Murrell W. D., Prasad A., Verborgt O.Review Article, 35 - 47 -
Nutraceutical supplement in the management of tendinopathies: a systematic review
Fusini F., Bisicchia S., Bottegoni C., Gigante A., Zanchini F., Busilacchi A.Review Article, 48 - 57 -
Acute augmentation for interstitial insufficiency of the posterior cruciate ligament. A two to five year clinical and radiographic study
Wai-kit Chan T., Kong C.C., Del Buono A., Maffulli N.Review Article, 58 - 63 -
Medial patello-femoral ligament (MPFL) reconstruction using suture anchors fixation: preliminary results
Calanna F., Pulici L., Carimati G., Quaglia A., Volpi P.Original Article, 64 - 70 -
Meniscus tear surgery and meniscus replacement
Vaquero J., Forriol F.Review Article, 71 - 89 -
Microcirculation in healing and healthy Achilles tendon assessed with invasive laser doppler flowmetry
Arverud E.D., Persson-Lindell O., Sundquist F., Labruto F., Edman G., Ackermann P.W.Original Article, 90 - 96 -
Previous physical exercise slows down the complications from experimental diabetes in the calcaneal tendon
Bezerra M.A., da Silva Nery C., de Castro Silveira P.V., de Mesquita G.N., de Gomes Figueiredo T., Holanda Barboza Inácio Teixeira M.F., Arruda de Moraes S.R.Original Article, 97 - 103 -
Extended field of view ultrasound imaging to evaluate Achilles tendon length and thickness: a reliability and validity study
Silbernagel K.G., Shelley K., Powell S., Varrecchia S.Original Article, 104 - 110 -
Different distributions of operative diagnoses for Achilles tendon overuse injuries in Italian and Finnish athletes
Johansson K., Lempainen L., Sarimo J., Laitala-Leinonen T., Orava S.Original Article, 111 - 115 -
Prediction of hamstring injury in professional soccer players by isokinetic measurements
Dauty M., Menu P., Fouasson-Chailloux A., Ferréol S., Dubois COriginal Article, 116 - 123 -
Epidemiology of soccer players traumatic injuries during the 2015 America Cup
Pangrazio O., Forriol F.Original Article, 124 - 130 -
“Efficacy of betamethasone valerate medicated plaster on painful chronic elbow tendinopathy: a double-blind, randomized, placebo-controlled trial”
Frizziero A., Causero A., Bernasconi S., Papala R., Longo M., Sessa V., Sadile F., Greco P., Tarantino U., Masiero S., Rovati S., Frangione V.Original Article, 131 -139 -
Supinated forearm is correlated with the onset of medial epicondylitis in professional slalom waterskiers
Rosa D., Di Donato S.L., Balato G., D’Addona A., Schonauer F.Original Article, 140 - 146 -
Clinical applications of vibration therapy in orthopaedic practice
Cerciello S., Rossi S., Visonà E., Corona K., Oliva F.Original Article, 147 - 156 -
“CrossFit athletes exhibit high symmetry of fundamental movement patterns. A cross-sectional study”
Tafuri S., Notarnicola A., Monno A., Ferretti F., Moretti B.Original Article, 157 - 160 -
Association of the type of trauma, occurrence of bone bruise, fracture and joint effusion with the injury to the menisci and ligaments in MRI of knee trauma
Pezeshki S., Vogl T.J., Pezeshki M.Z., Hossein Daghighi M., Pourisa M.Original Article, 161 - 166 -
Ultrasonography for the assessment of the upper trapezius properties in healthy females: a reliability study
Adigozali H., Shadmehr A., Ebrahimi E., Rezasoltani A-, Naderi F.Original Article, 167 - 172