| We aim to identify current in vitro research exploring platelet-rich plasma (PRP) effects in human Mesenchymal Stem Cells (MSCs) that may encourage or limit the clinical application of MSCs along with PRP. After a systematic search, we identified 57 in vitro studies, focused on optimization of MSC manufacturing, and expanding knowledge about how PRP modifies MSCs behavior for translational purposes. Influences of PRP on proliferation, migration, stemness, preservation of MSC immune-modulatory properties and appearance of senescence phenotype have been explored. Overall PRP stimulates MSC proliferation, preserves MSCs multipotency and does not interfere with any lineage differentiation. PRP (as platelet lysate or releasate) preserves the immune-privileged potential of MSCs and may delay the appearance of the senescent phenotype. Currently there are few data linking precise molecules and biological mechanisms. Various gaps of knowledge need to be addressed in order to obtain enough useful information for translational purposes. |
Partnership between platelet-rich plasma and mesenchymal stem cells: in vitro experience
Rubio-Azpeitia E., Andia I.
Review Article, 52 - 62
Keywords: cell culture, in vitro., mesenchymal stem cells (MSC), platelet-rich plasma (PRP), regenerative medicine, tissue engineering.,
Table of Content: Vol. 4 (No. 1) 2014 January/March
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Platelet rich plasma therapies: a great potential to be harnessed
Andia I.Editorial, 1 - 2 -
PRP treatment effects on degenerative tendinopathy – an in vitro model study
Zhang J., Wang J.H.C.Original Article, 10 - 17 -
Impact of local anaesthetics and needle calibres used for painless PRP injections on platelet functionality
Bausset O., Magalon J., Giraudo L., Loui M.-L., Serratrice N., Frere C., Magalon G., Dignat-George F., Sabatier F.Original Article, 18 - 23 -
Sonographic findings during and after Platelet Rich Plasma injections in tendons
Abate M., Verna S., Di Gregorio P., Salini V., Schiavone C.Original Article, 29 - 34 -
Learning about PRP using cell-based models
Beitzel K., McCarthy M.B., Russell R.P., Apostolakos J., Cote M.P., Mazzocca A.D.Review Article, 38 - 45 -
Mesenchymal stem cell response to growth factor treatment and low oxygen tension in 3-dimensional construct environment
Durant T.J.S., Dyment N., McCarthy M.B.R., Cote M.P., Arciero R.A., Mazzocca A.D., Rowe D.Original Article, 45 - 51 -
Partnership between platelet-rich plasma and mesenchymal stem cells: in vitro experience
Rubio-Azpeitia E., Andia I.Review Article, 52 - 62 -
Tendon structure, disease, and imaging
Weinreb J.H., Sheth C., Apostolakos J., McCarthy M.B., Barden B., Cote M.P., Mazzocca A.D.Review Article, 66 - 73 -
In vitro evaluation of the anti-bacterial effect of two preparations of platelet rich plasma compared with cefazolin and whole blood
Intravia J., Allen D.A., Durant T.J.S., McCarthy M.B.R., Russell R., Beitzel K., Cote M.P., Dias F., Mazzocca A.D.Article, 79 - 84 -
The use of odds ratio in the large population-based studies: Warning to readers
Di Lorenzo L., Coco V., Forte F., Trinchese G.F., Forte A.M., Pappagallo M.Letter to the Editor, 90 - 92 -
Meniscal sutures with outside-in technique: our experience with a less expensive method
Calderazzi F., Violi C., Paraskevopoulos A., Schiavi P., Ceccarelli F.Letter to the Editor, 93 - 94 -
No difference at two years between all inside transtibial technique and traditional transtibial technique in anterior cruciate ligament reconstruction
Volpi P., Balt C., Cervellin M., Denti M., Prospero E., Morenghi E., Quaglia A.Letter to the Editor, 95 - 99