|The ideal strategy for tendon healing has not been identified to date. Recently, the use of stem cells based therapy has been proposed, due to their ability to proliferate and to differentiate towards specific connective tissues lineages.
Embryonic stem cells should be considered the ideal cell source for regenerative therapies, but ethical factors limit their use in humans. Mesenchymal stem cells are more easily available and can be obtained by different sources. Amnion derived stem cells can differentiate towards all three germ layers, and can be used for allogeneic transplantation and stored thanks to cryopreservation.
In veterinary medicine, stem cells have been used with encouraging results for the treatment of the Superficial
Digital Flexor tendinopathy in the horses.
Considering that Superficial Digital Flexor tendinopathy is similar for pathogenesis and histopathology to Achilles tendinopathy in man, this experience can provide supportive data to encourage the use of regenerative therapy in humans.
Stem cell therapy of tendinopathies: suggestions from veterinary medicine
Muttini A., Salini V., Valbonetti L., Abate M.
Review Article, 187 - 192
Keywords: Achilles tendon, stem cells, tendinopathy,
Table of Content: Vol. 2 (No. 3) 2012 July/September
Berardi A. C., Oliva F.Editorial, 153
Po Yee Lui P., Wong O.T.Review Article, 163 - 168
Delaine-Smith R.M., Reilly G.C.Review Article, 169 - 180
Muttini A., Salini V., Valbonetti L., Abate M.Review Article, 187 - 192
Filomeno P., Dayan V., Tourino C.Review Article, 204 - 211
The role of microvesicles derived from mesenchymal stem cells in tissue regeneration; a dream for tendon repair?Tetta C., Consiglio A.L., Bruno S., Tetta E., Gatti E., Dobreva M., Cremonesi F., Camussi G.Review Article, 212 - 221
Chaudhury S.Review Article, 222 - 229
Rizzi R., Bearzi C., Mauretti A., Bernardini S., Cannata S., Gargioli C.Review Article, 230 - 234
Ruzzini L., Longo U.G., Rizziello G., Denaro V.Mini-Review, 235 - 238
Raggi C., Berardi A. C.Mini-Review, 239 - 242