| The non-enzymatic reaction of proteins with glucose (glycation) is a topic of rapidly growing importance in human health and medicine. There is increasing evidence that this reaction plays a central role in ageing and disease of connective tissues. Of particular interest are changes in type-I collagens, long-lived proteins that form the mechanical backbone of connective tissues in nearly every human organ. Despite considerable correlative evidence relating extracellular matrix (ECM) glycation to disease, little is known of how ECM modification by glucose impacts matrix mechanics and damage, cell-matrix interactions, and matrix turnover during aging. More daunting is to understand how these factors interact to cumulatively affect local repair of matrix damage, progression of tissue disease, or systemic health and longevity. This focused review will summarize what is currently known regarding collagen glycation as a potential driver of connective tissue disease. We concentrate attention on tendon as an affected connective tissue with large clinical relevance, and as a tissue that can serve as a useful model tissue for investigation into glycation as a potentially critical player in tissue fibrosis related to ageing and diabetes. |
The role of collagen crosslinks in ageing and diabetes – the good, the bad, and the ugly
Snedeker J.G., Gautieri A.
Review Article, 303 - 308
Keywords: advanced glycation endproducts, ageing., collagen, crosslinks, diabetes, tendon mechanics,
Table of Content: Vol. 4 (No. 3) 2014 July/September
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Metabolic diseases and tendinopathies: the missing link
Oliva F., Misiti S., Maffulli N.Editorial, 273 - 274 -
Exploring the role of hypercholesterolemia in tendon health and repair
Hast M.W., Abboud J.A., Soslowsky L.JReview Article, 275 - 279 -
Biomechanical properties and histology of db/db diabetic mouse Achilles tendon
Boivin G.P., Elenes E.Y., Schultze A.K., Chodavarapu H., Hunter S.A., Elase K.M.Original Article, 280 - 284 -
Thyroid hormones increase collagen I and cartilage oligomeric matrix protein (COMP) expression in vitro human tenocytes
Berardi A.C., Oliva C., Berardocco M., La Rovere M., Accorsi P., Maffulli N.Original Article, 285 - 291 -
Angiogenic and innate immune responses triggered by PRP in tendon cells are not modified by hyperuricemia
Andia I., Rubio-Azpeitia E.Original Article, 292 - 297 -
How obesity modifies tendons (implications for athletic activities)
Abate M.Review Article, 298 - 302 -
The role of collagen crosslinks in ageing and diabetes – the good, the bad, and the ugly
Snedeker J.G., Gautieri A.Review Article, 303 - 308 -
Epidemiology of the rotator cuff tears: a new incidence related to thyroid disease
Oliva F., Osti L., Padulo J., Maffulli N.Original Article, 309 - 314 -
Functional adaptation of tendon and skeletal muscle to resistance training in three patients with genetically verified classic Ehlers Danlos Syndrome
Møller M.B., Kjær M., Svensson R.B., Andersen J.L., Magnusson S.P., Nielsen R.H.Original Article, 315 - 323 -
Impact of oestrogen deficiency and aging on tendon: concise review
Frizziero A., Vittadini F., Gasparre G., Masiero S.Review Article, 324 - 328 -
Cushing, acromegaly, GH deficiency and tendons
Galdiero M., Auriemma R.S., Pivonello R., Colao A.Review Article, 329 - 332 -
The enthesis: a review of the tendon-to-bone insertion
Apostolakos J., Durant T.J.S., Dwyer C.R., Russell R.P., Weinreb J.H., Alaee F., Beitzel K., McCarthy M.B.R., Cote M.P., Mazzocca A.D.Review Article, 333 - 342 -
Tendon to bone healing and its implications for surgery
Bunker D.L. J., Illie V., Illie V., Nicklin S.Review Article, 343 - 350 -
Combined intra-tendinous injection of Platelet Rich Plasma and bevacizumab accelerates and improves healing compared to Platelet Rich Plasma in tendinosis: comprehensive assessment on a rat model
Dallaudiere B., Zurlinden O., Perozziello A., Deschamps L., Larbi A., Louedec L., Pesquer L., Benayoun Y., Silvestre Y., Serfaty J.M.Original Article, 351 - 356 -
Experimental studies on the biological effects of extracorporeal shock wave therapy on tendon models. A review of the literature
Visco V., Vulpiani M.C., Torrisi M.R., Ferretti A., Pavan A., Vetrano M.Review Article, 357 - 361 -
Matrix metalloproteinase-2 plays a critical role in overload induced skeletal muscle hypertrophy
Zhang Q., Joshi S.K., Lovett D.H., Zhang B., Bodine S., Kim H., Liu X.Original Article, 362 - 370 -
“Physical principles demonstrate that the biceps femoris muscle relative to the other hamstring muscles exerts the most force: implications for hamstring muscle strain injuries”
Dolman B., Verrall G., Reid I.Original Article, 371 - 377 -
Growth factor delivery vehicles for tendon injuries: Mesenchymal stem cells and Platelet Rich Plasma
Guevara-Alvarez A., Schmitt A., Russell R.P., Imhoff A.B., Buchmann S.Review Article, 378 - 385 -
Clinical predictors of time to return to competition following hamstring injuries
Guillodo Y., Here-Dorignac C., Thoribé B., Madouas G., Dauty M., Tassery F., Saraux A.Original Article, 386 - 390 -
Classification of rotator cuff tendinopathy using high definition ultrasound
Hinsley H., Nicholls A., Daines M., Wallace G., Arden N., Carr A.Original Article, 391 - 397