|Background: the application of thermal energy (TE) has shown promise in the treatment of tendinopathy. However, the precise mechanism(s) of action of this therapy is unclear. The loss of tendon cell homeostatic tension, due to loadinginduced laxity, produces catabolic changes associated with tendinopathy. This catabolic activity can be inhibited through the re-establishment of a normal tensile environment via a cellular contraction mechanism. We hypothesized that application of TE will enhance the contraction rate of lax rat tail tendon fascicles (RTTfs) in an in vitro model.
Methods: following loading, 10 lax RTTfs from each mature rat (n=5) were treated once daily for 7 days with TE by replacing the culture media at 37˚C (control) with 42˚C media. Using calibrated photographs, RTTf lengths were measured daily.
Additional RTTfs were utilized to investigate any changes in material (n=12) and/or histological (n=12) properties with TE.
Results: TE significantly increased the contraction rate of RTTfs (p>0.001) without altering the material or histological properties.
Conclusion: these results demonstrate that TE significantly enhances the contraction rate of previously exercised tendons. The ability to more quickly re-establish a normal mechanobiological environment, thus minimizing any catabolic changes, may explain the beneficial effects reported with applied TE in tendinopathy treatment.
Thermal energy enhances cell-mediated contraction of lax rat tail tendon fascicles following exercise
Lavagnino M., Malek K., Gardner K.L., Arnoczky S.P.
Original Article, 51 - 55
Keywords: contraction, laxity, rat tail tendon, tendinopathy, thermal energy,
Table of Content: Vol. 5 (No. 1) 2015 January/March
Kaux J-F., Bouvard M., Lecut C., Oury C., Gothot A., Sanchez M., Crielaard J-MTechnical Notes, 1 - 4
Identification of normal and pathological posterior inter-malleolar ligament with dedicated high-field vs low-field MRI. A pilot studySutera R., Bianco A., Paoli A., Padulo J., Thomas E., Iovane A., Palma A.Original Article, 12 - 17
Rambani R., Hackney R.Original Article, 29 - 32
Shortness of filum terminale represents an anatomical specific feature in fibromyalgia: a nuclear magnetic resonance and clinical studyMantia R., Di Gesù M., Vetro A., Mantia F., Palma S., Iovane A.Original Article, 33 - 37
Vando S., Laffaye G., Masala D., Falese L., Padulo J.Technical Note, 43 - 44
Thermal energy enhances cell-mediated contraction of lax rat tail tendon fascicles following exerciseLavagnino M., Malek K., Gardner K.L., Arnoczky S.P.Original Article, 51 - 55