| Background: the application of thermal energy (TE) has shown promise in the treatment of tendinopathy. However, the precise mechanism(s) of action of this therapy is unclear. The loss of tendon cell homeostatic tension, due to loadinginduced laxity, produces catabolic changes associated with tendinopathy. This catabolic activity can be inhibited through the re-establishment of a normal tensile environment via a cellular contraction mechanism. We hypothesized that application of TE will enhance the contraction rate of lax rat tail tendon fascicles (RTTfs) in an in vitro model. Methods: following loading, 10 lax RTTfs from each mature rat (n=5) were treated once daily for 7 days with TE by replacing the culture media at 37˚C (control) with 42˚C media. Using calibrated photographs, RTTf lengths were measured daily. Additional RTTfs were utilized to investigate any changes in material (n=12) and/or histological (n=12) properties with TE. Results: TE significantly increased the contraction rate of RTTfs (p>0.001) without altering the material or histological properties. Conclusion: these results demonstrate that TE significantly enhances the contraction rate of previously exercised tendons. The ability to more quickly re-establish a normal mechanobiological environment, thus minimizing any catabolic changes, may explain the beneficial effects reported with applied TE in tendinopathy treatment. |
Thermal energy enhances cell-mediated contraction of lax rat tail tendon fascicles following exercise
Lavagnino M., Malek K., Gardner K.L., Arnoczky S.P.
Original Article, 51 - 55
Keywords: contraction, laxity, rat tail tendon, tendinopathy, thermal energy,
Table of Content: Vol. 5 (No. 1) 2015 January/March
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Reflections about the optimisation of the treatment of tendinopathies with PRP
Kaux J-F., Bouvard M., Lecut C., Oury C., Gothot A., Sanchez M., Crielaard J-MTechnical Notes, 1 - 4 -
“Pilot experimental study on amniotic epithelial mesenchymal cell transplantation in natural occurring tendinopathy in horses. Ultrasonographic and histological comparison”
Original Article, 5 - 11 -
Identification of normal and pathological posterior inter-malleolar ligament with dedicated high-field vs low-field MRI. A pilot study
Sutera R., Bianco A., Paoli A., Padulo J., Thomas E., Iovane A., Palma A.Original Article, 12 - 17 -
Acute compartment syndrome
Giai Via A., Oliva F., Spoliti M., Maffulli N.Review Article, 18 - 22 -
Expert opinion: diagnosis and treatment of proximal hamstring tendinopathy
Lempainen L., Johansson K., Banke I.J., Ranne J., Mäkelä K., Sarimo J., Niemi P., Orava S.Mini-Review, 23 - 28 -
Loss of range of motion of the hip joint: a hypothesis for etiology of sports hernia
Rambani R., Hackney R.Original Article, 29 - 32 -
Shortness of filum terminale represents an anatomical specific feature in fibromyalgia: a nuclear magnetic resonance and clinical study
Mantia R., Di Gesù M., Vetro A., Mantia F., Palma S., Iovane A.Original Article, 33 - 37 -
Day-time effect on postural stability in young sportsmen
Russo L., D'Eramo U., Padulo J., Foti C., Schiffer R., Scoppa F.Original Article, 38 - 42 -
Reliability of the Wii Balance Board in kayak
Vando S., Laffaye G., Masala D., Falese L., Padulo J.Technical Note, 43 - 44 -
Focal Myositis in paediatric age
Gigante C., Corradin M., Alaggio R.Case Report, 45 - 50 -
Thermal energy enhances cell-mediated contraction of lax rat tail tendon fascicles following exercise
Lavagnino M., Malek K., Gardner K.L., Arnoczky S.P.Original Article, 51 - 55