| Background: we previously demonstrated the presence of high levels of thyroid hormones (THs) receptors isoforms in healthy tendons, their protective action during tenocyte apoptosis, and the capability to enhance tenocyte proliferation in vitro. In the present study we tested the ability of THs to influence ECM protein tenocyte secretion in an in vitro system. Methods: primary tenocyte-like cells were cultivated for 1, 7 and 14 days in the presence of T3 or T4 individually or in combination with ascorbic acid (AA). Results: THs (T3 or T4) in synergism with AA increase significantly the total collagen production after 14 days. THs in synergism with AA increase significantly the expression of collagen I,biglycan and COMP, after some days. Conclusion: THs play a role on the extra cellular matrix of tendons, enhancing in vitro the production of several proteins such as collagen I, biglycan and COMP. THs receptors are active on human tenocytes, and can play a role in tendon ailments. |
Thyroid hormones increase collagen I and cartilage oligomeric matrix protein (COMP) expression in vitro human tenocytes
Berardi A.C., Oliva C., Berardocco M., La Rovere M., Accorsi P., Maffulli N.
Original Article, 285 - 291
Keywords: ascorbic acid, collagen I, COMP, tendons, tenocytes, thyroid hormones,
Table of Content: Vol. 4 (No. 3) 2014 July/September
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Metabolic diseases and tendinopathies: the missing link
Oliva F., Misiti S., Maffulli N.Editorial, 273 - 274 -
Exploring the role of hypercholesterolemia in tendon health and repair
Hast M.W., Abboud J.A., Soslowsky L.JReview Article, 275 - 279 -
Biomechanical properties and histology of db/db diabetic mouse Achilles tendon
Boivin G.P., Elenes E.Y., Schultze A.K., Chodavarapu H., Hunter S.A., Elase K.M.Original Article, 280 - 284 -
Thyroid hormones increase collagen I and cartilage oligomeric matrix protein (COMP) expression in vitro human tenocytes
Berardi A.C., Oliva C., Berardocco M., La Rovere M., Accorsi P., Maffulli N.Original Article, 285 - 291 -
Angiogenic and innate immune responses triggered by PRP in tendon cells are not modified by hyperuricemia
Andia I., Rubio-Azpeitia E.Original Article, 292 - 297 -
How obesity modifies tendons (implications for athletic activities)
Abate M.Review Article, 298 - 302 -
The role of collagen crosslinks in ageing and diabetes – the good, the bad, and the ugly
Snedeker J.G., Gautieri A.Review Article, 303 - 308 -
Epidemiology of the rotator cuff tears: a new incidence related to thyroid disease
Oliva F., Osti L., Padulo J., Maffulli N.Original Article, 309 - 314 -
Functional adaptation of tendon and skeletal muscle to resistance training in three patients with genetically verified classic Ehlers Danlos Syndrome
Møller M.B., Kjær M., Svensson R.B., Andersen J.L., Magnusson S.P., Nielsen R.H.Original Article, 315 - 323 -
Impact of oestrogen deficiency and aging on tendon: concise review
Frizziero A., Vittadini F., Gasparre G., Masiero S.Review Article, 324 - 328 -
Cushing, acromegaly, GH deficiency and tendons
Galdiero M., Auriemma R.S., Pivonello R., Colao A.Review Article, 329 - 332 -
The enthesis: a review of the tendon-to-bone insertion
Apostolakos J., Durant T.J.S., Dwyer C.R., Russell R.P., Weinreb J.H., Alaee F., Beitzel K., McCarthy M.B.R., Cote M.P., Mazzocca A.D.Review Article, 333 - 342 -
Tendon to bone healing and its implications for surgery
Bunker D.L. J., Illie V., Illie V., Nicklin S.Review Article, 343 - 350 -
Combined intra-tendinous injection of Platelet Rich Plasma and bevacizumab accelerates and improves healing compared to Platelet Rich Plasma in tendinosis: comprehensive assessment on a rat model
Dallaudiere B., Zurlinden O., Perozziello A., Deschamps L., Larbi A., Louedec L., Pesquer L., Benayoun Y., Silvestre Y., Serfaty J.M.Original Article, 351 - 356 -
Experimental studies on the biological effects of extracorporeal shock wave therapy on tendon models. A review of the literature
Visco V., Vulpiani M.C., Torrisi M.R., Ferretti A., Pavan A., Vetrano M.Review Article, 357 - 361 -
Matrix metalloproteinase-2 plays a critical role in overload induced skeletal muscle hypertrophy
Zhang Q., Joshi S.K., Lovett D.H., Zhang B., Bodine S., Kim H., Liu X.Original Article, 362 - 370 -
“Physical principles demonstrate that the biceps femoris muscle relative to the other hamstring muscles exerts the most force: implications for hamstring muscle strain injuries”
Dolman B., Verrall G., Reid I.Original Article, 371 - 377 -
Growth factor delivery vehicles for tendon injuries: Mesenchymal stem cells and Platelet Rich Plasma
Guevara-Alvarez A., Schmitt A., Russell R.P., Imhoff A.B., Buchmann S.Review Article, 378 - 385 -
Clinical predictors of time to return to competition following hamstring injuries
Guillodo Y., Here-Dorignac C., Thoribé B., Madouas G., Dauty M., Tassery F., Saraux A.Original Article, 386 - 390 -
Classification of rotator cuff tendinopathy using high definition ultrasound
Hinsley H., Nicholls A., Daines M., Wallace G., Arden N., Carr A.Original Article, 391 - 397