SUMMARY
Objective. Rheumatoid arthritis (RA) is an inflammatory disease. Here we analyzed the effects of the supplementation with curcumin (CM) in a treatment with prednisone (PD) on hind paw’ functionality and rectus femoris histomorphometric and immunohistochemical aspects.
Methods. Thirty female 18 months-old Wistar rats were divided in six groups: control (CG), arthritis (AG), arthritis CM (AC), arthritis PD low-dose (APLD), arthritis PD high-dose (APHD) and arthritis PD low-dose and CM (APLDC). The experimental RA was induced by a complete Freund’s adjuvant injection into the knee joint cavity. PD (2 mg/kg/day and 10 mg/kg/day) and CM (C21H20O6) (100 mg/kg/day) were used as treatment, using gavage method. Functionality, histomorphometric and immunohistochemical evaluations were performed in the hind paw and in the rectus femoris muscle. Generalized mixed models was used for statistical analysis. Statistical significance was set as P-value 0.05.
Results. AG had loss of grip strength, motor function and increase in nociceptive threshold (p < 0.0001). AC and APLDC had positive effects on grip strength and motor function. Histomorphometry revealed degenerative lesions in AG muscular tissue with circulatory disorders, changes in muscle fibers, connective tissue and muscle spindle, major total collagen quantity and smaller perimeter in the postsynaptic region (p < 0.0001). APLDC showed the best recovery in these aspects (p < 0.001).
Conclusions. CM supplementation in the treatment with 2 mg/kg/day of PD restored muscle strength, motor function, histomorphometrical and postsynaptic aspects in old female rats with experimentally induced RA.
Curcumin (Curcuma longa) Supplementation Associated with Low-Dose Prednisone Improves Morphofunctional, Histomorphometric and Postsynaptic Aspects of the Rectus Femoris Muscle in Old Female Wistar Rats with Experimental Rheumatoid Arthritis
Ana Caroline Barbosa Retameiro, Carolina de Toni Boaro, Diego Francis Saraiva Rodriguez, Taciane Stein, Aldair Casagrande dos Santos, Jurandyr Pimentel Neto, Adriano Polican Ciena, Márcia Miranda Torrejais, Rose Meire Costa, Gladson Ricardo Flor Bertolini, Lucinéia de Fátima Chasko Ribeiro
Original Article, 553-566
Keywords: Neuromuscular junction; turmeric; arthritis; morphometry; immunohistochemistry,
Table of Content: Vol. 14 (No.4) 2024 October/December
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Simultaneous Ligament Injury in Osteochondral Lesions of Talus in MRI Scans
Alireza Mousavian, Ahmad GhayourKazemi, Mohammadhossein Ebrahimzadeh, Negin HadadanOriginal Article, 507-513 -
Physical Activity, A Polypill for Non-Communicable Diseases in Modern era: a Scoping Review
Baskaran Chandrasekaran, Mayur Raju CougneryREVIEW, 514-537 -
Effects of Ischemic Preconditioning or Self-Myofascial Release on Muscle Power in Men Trained
Alex Souto Maior, Angelo NovariniOriginal Article, 538-544 -
Reliability and Validity of Digital Inclinometer in Assessing Ankle Dorsiflexion: A Focus on First Detectable Resistance Position in Individuals With and Without Achilles Tendinopathy
Daniel Nogueira Barreto de Melo, Paloma Almeida Pereira, Márcio Almeida Bezerra, Rodrigo Ribeiro de OliveiraOriginal Article, 542-552 -
Curcumin (Curcuma longa) Supplementation Associated with Low-Dose Prednisone Improves Morphofunctional, Histomorphometric and Postsynaptic Aspects of the Rectus Femoris Muscle in Old Female Wistar Rats with Experimental Rheumatoid Arthritis
Ana Caroline Barbosa Retameiro, Carolina de Toni Boaro, Diego Francis Saraiva Rodriguez, Taciane Stein, Aldair Casagrande dos Santos, Jurandyr Pimentel Neto, Adriano Polican Ciena, Márcia Miranda Torrejais, Rose Meire Costa, Gladson Ricardo Flor Bertolini, Lucinéia de Fátima Chasko RibeiroOriginal Article, 553-566 -
Core Strengthening Improves Pain in Women with Patellofemoral Pain: a Feasibility Interventional Trial
Renan Andrade Pereira Barbosa, Juliane da Silva Flôr, Bianca Sabino Rodrigues, Rafael Inácio Barbosa, Alexandre Márcio Marcolino, Heloyse Uliam KurikiOriginal Article, 567-576 -
Nociceptive and Inflammatory Evaluation of Water Jumping in Wistar Rats with a Rheumatoid Arthritis Model
Alana Ludemila de Freitas Tavares, Morgana Neves, Thaís Caroline Schnauffer, Lilian Pradal, Taciane Stein da Silva Leal, Lucineia de Fátima Chasko Ribeiro, Gladson Ricardo Flor BertoliniOriginal Article, 577-585 -
Bilateral Symmetries and Conventional Torque Hamstrings: Quadriceps (H:Q) Ratio in Different Sports
Tiago Dutra Leite-Nunes, Michele Forgiarini Saccol, Silvana Corrêa Matheus, Daniela Lopes dos Santos, Fábio Juner LanferdiniOriginal Article, 586-593 -
Effect of Toe Walking Exercises and Intrinsic Foot Muscle Exercises for Individuals With Flat Foot: A Comparative Study
Hemalatha S., Senthil Kumar S., Nimalan P., Bismi Farhana M., Jeberson J.Original Article, 594-600 -
Comparison of Intersegmental Coordination and Movement Variability in Athletes with and without Persistent Low Back Pain
Sajjad Abdollahi, Rahman Sheikhhoseini, Wendy E. HuddlestonOriginal Article, 601-613 -
Exploring Neurokinetic Therapy on Core Muscle Endurance, Lateral Pelvic Tilt, and Quadratus Lumborum Flexibility for subjects with Chronic Non-Specific Low Back Pain
Mohammed Luqman Sulaiman, Kamalakannan Mohanan, Kotteeswaran Kandaswami, Durga NagarajOriginal Article, 614-622 -
Ref: Ferreira Pedrosa et al. More Training, Less Trainability: True? A muscle Swelling Analysis (doi: 10.32098/mltj.03.2024.03)
Vinnycius Nunes de OliveiraLetter to the Editor, 623-624 -
Reply to: “Ref: Ferreira Pedrosa et al. More Training, Less Trainability: True? A muscle Swelling Analysis”
Gustavo Ferreira Pedrosa, Lorenzo Laporta, Maria E. C. Rigo, Lair A. C. de Souza, Tiago D. L. Nunes, Michele Forgiarini Saccol, Henrique de Oliveira Castro, Gustavo De Conti Teixeira Costa, Arthur B. G. Bischoff, Thiago Alexandro Nascimento De AndradeReply, 625-626