SUMMARY
Background. The ankle joint is a frequent site of injury and bone remodeling, and often requires cartilage repair. Studies have shown that growth factors and bioactive compounds have regenerative properties capable of promoting cartilage restoration.
Hyaluronic acid (HA) and orthobiologics like platelet-rich plasma (PRP) and adult stem cells (ASCs) are particularly interesting as therapeutic solutions for ankle cartilage repair and have received considerable attention over the years.
Methods. We performed a literature review to summarize the clinical uses and outcomes of HA, PRP and ASCs as reparative interventions in osteochondral lesions (OCL) and osteoarthritis (OA) of the ankle, when used alone and post-surgically.
Results. In total, 50 studies were eligible and included in this review. HA was shown to be a safe treatment option with a low rate of adverse effects and overall clinical improvement for talar OCL when used alone and post-surgically. PRP was found to be superior to HA for talar OCL in non-surgical and post-surgical patients. Studies evaluating HA injections for ankle OA noted a general improvement in pain and function post-injection with minimal adverse reactions, though there is mixed data regarding the efficacy of PRP injections for ankle OA. High-level randomized controlled trials are lacking for the evaluation of ASCs in talar OCL and ankle OA, though limited research has found them to be safe and efficacious.
Conclusions. HA and orthobiologics can be considered for use as a pre-surgical treatment in ankle OCL and OA, or as a second-line treatment for patients who remain symptomatic after surgery. The safety profile and subjective improvement in clinical outcomes following orthobiologic treatments is promising, though requires additional
investigation.
Orthobiologic Injectables in the Ankle Joint: a Narrative Review
E. Y. Roh, M. S. Rana, K. C. McInnis, D. R. Bakal, H. Borgstrom, J. Borg-Stein
Review, 453-477
Keywords: adult stem cells, ankle osteoarthritis, BMAC, hyaluronic acid., mesenchymal stem cells, MFAT, platelet rich plasma, talar osteochondral lesions,
Table of Content: Vol. 12 (No.4) 2022 October/December
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Orthobiologic Injectables in the Ankle Joint: a Narrative Review
E. Y. Roh, M. S. Rana, K. C. McInnis, D. R. Bakal, H. Borgstrom, J. Borg-SteinReview, 453-477 -
Achilles Tendon Rupture in Professional Football Player: an Epidemiological Study in European Championship With A Mid-Term Follow-Up
D. Mazza, A. Annibaldi, E. Monaco, A. Carrozzo, G. Princi, S. Fenucci, E. Viglietta, S. Porcino, G. Rossi, A. FerrettiOriginal Article, 478-483 -
Insertional Achilles Tendon Repair with Bioabsorbable Anchors and Suture
R. L. Conle (né Gaudin), A. SaxenaOriginal Article, 484-489 -
Inflammatory Response of Skeletal Muscles to a High-Fat Diet
I. V. Dimitrov, T. R. Stankova, P. A. Angelova, N. P. Boyadjiev, K. N. Georgieva, D. I. Popov, I. Dimov, A. V. Bivolarska, F. D. Gerginska, E. P. Daskalova, M. N. Draganova-Filipova, S. D. DelchevOriginal Article, 490-496 -
Association of Arthroscopically-Assisted Latissimus Dorsi Tendon Transfer with Implantation of a Subacromial Balloon Spacer for Patients with Irreparable Posterosuperior Rotator Cuff Tears
E. Gervasi, G. E. Vigni, P. S. Vezeridis, A. Tomasi, G. Sabbioni, F. Fazzari, L. CamardaOriginal Article, 497-510 -
Efficacy of Liposomal Bupivacaine in Arthroscopic Rotator Cuff Repair: a Systematic Review and Meta-Analysis of Randomized Controlled Trials
S. I. Alaqaili, M. F. Al-Saati, M. Y. Alyousef, M. A. Alzayer, A. S. Alsultan, M. M. Alzahrani, S. M. AlqahtaniReview, 511-521 -
The Effects of Neuromuscular Electric Stimulation on Pain, Function, Muscle Strength and Muscle Architecture in Patients with Rotator Cuff Tendinopathies
E. M. Ersever, N. A. Guzel, H. Genc, C. MulkogluOriginal Article, 522-529 -
The Upper Extremity Functional Index (UEFI): Cross-Cultural Adaptation, Reliability, and Validity of the Italian Version
M. D’Agostino, M. Panico, A. Marsocci, F. Angelini, F. Casile, A. Graffitti, F. MagnificaOriginal Article, 530-536 -
Evaluation of Serum Calcium, Phosphorus and Vitamin D Levels and History of Calcium and Vitamin D Supplementation in Patients with Calcified Shoulder Tendinopathy
H. Saremi, M. H. Bagheri, H. Naderifar, M. A. SeifrabieiOriginal Article, 537-541 -
Comparable Tibial Tunnel Widening despite Compound Differences of Bioabsorbable Interference Screws in Anterior Cruciate Ligament Reconstruction: a Retrospective Study
G. T. A. Krist, B. B. Koc, R. Borghans, M. G. M. Schotanus, E. J. P. JansenOriginal Article, 542-547 -
Morphological Study of the Transverse Ligament of Knee Joint in Embalmed Cadavers
V. S. Nayak, G. Ravishankar, B. V. Murlimanju, N. P. Bhat, S. S. Nayak, M. M. Pai, R. Vadgaonkar, L. V. PrabhuOriginal Article, 548-554 -
Effects of Ischemic Preconditioning on Functional and Neuromuscular Performance of Lower Limbs of Male Amateur Soccer Players: Protocol for a Randomized Trial
I. Martins de França, M. S. Cerqueira, S. Bezerra da Nobrega Neto, C. Augusto de Menezes Araújo, Y. M. Barros de Sousa Oliveira, W. H. de Brito VieiraOriginal Article, 555-561 -
Effect of Eight-Week Proprioceptive Neuromuscular Facilitation (PNF) Pattern-Based Exercises on Performance Scores and Postural Stability in Elite Men Basketball Players
A. Shamlou Kazemi, F. Babakhani, R. Sheikhhoseini, H. NaderifarOriginal Article, 562-569 -
Relation Between Components of Oral Health and Sarcopenia in Older Adults: a Narrative Review
P. Kumar, S. Varshney, N. GirishReview, 570-593 -
Fascicle Orientation of Superficial Back Muscles Attached to the Posterior Layer of the Thoracolumbar Fascia: a Morphometric Study Using Human Cadavers
S. Marpalli, M. K. G. Rao, P. Venkatesan, B. M. GeorgeOriginal Article, 594-599 -
Evaluation of Torque, Electromyographic Activity and Neuromuscular Efficiency of the Internal Oblique Muscle in Pilates Practitioners
A. C. Panhan, M. Gonçalves, C. Cirino, A. C. Cardozo, F. Bérzin (deceased)Original Article, 600-603 -
Stabilization Exercises versus Flexi-Bar Exercises in Chronic Non-Specific Low Back Pain: Pain, Disability, Back Muscles Endurance. A Randomized Controlled Trial
F. Amiri, M. Mohsen Roostayi, S. S. Naimi, A. Akbarzadeh BaghbanOriginal Article, 604-614 -
Ultrasound-Guided Injection of Low Molecular Weight Hyaluronic Acid versus Steroid for Inflammatory and Degenerative Sacroiliitis: a Single-Blinded Randomized Controlled Trial
M. Abdelkreem, K. Hussein, A. MoshrifOriginal Article, 615-620 -
The Effects of Lower Crossed Syndrome on Upper Body Posture during Sitting in Female Office Workers
P. Puagprakong, A. Kanjanasilanont, K. Sornkaew, W. S. BradyOriginal Article, 621-627