Combining Platelet Rich Plasma and Concentrated Bone Marrow with a Demineralized Bone Matrix Scaffold Enhances Growth Factor Release Over Time

SUMMARY Background. Scaffolds composed of demineralized bone matrix (DBM) enriched with platelet rich plasma (PRP) and concentrated bone marrow-derived mesenchymal stem cells (concentrated bMSCs) may be able to release growth factors over time. The hypothesis is that the combination of PRP + bMSCs + DBM will result in high levels of growth factor release over … Continued

Concentrated Bone Marrow Aspirate and Subacromial Bursa-Derived Cells Demonstrate Similar Cellular Adhesion and Proliferation Potential on Demineralized Bone Matrix Scaffolds for Biologic Augmentation of Rotator Cuff Repair

SUMMARY Background. Specific scaffolds are still required to sufficiently deliver and retain applied mesenchymal stem cells (MSCs) of various origins to the targeted zone of repaired tissue. The purpose of the study was to evaluate the demineralized bone matrix (DBM) as a scaffold for concentrated bone marrow aspirate (cBMA), subacromial bursa-derived cells (SBDCs), tenocytes, and … Continued