Does the Antimalarial Drug Quinine Contribute to Muscle Fibro/Adipogenic Progenitor Fibrogenesis?

SUMMARY Background. In many resource-limited countries, children are routinely given intramuscular (IM) injections of medication to treat pain or illness. IM injections are suspected in the development of gluteal fibrosis (GF) in children, a condition that limits normal hip motion and function. The mechanism by which GF develops is not understood. Our study examines a … Continued

The Role of Fibro-Adipogenic Progenitors in Musculoskeletal Disease

SUMMARY Skeletal muscle consists of heterogeneous cell populations that work in concert to support musculoskeletal homeostasis and regeneration in the context of acute injury and chronic disease. In this past decade, the recently discovered sub-population of muscle resident stem cells known as fibro-adipogenic progenitors (FAPs) have been implicated in the pathogenesis and regenerative response to a number of … Continued