Orthobiologic Injectables in the Ankle Joint: a Narrative Review

SUMMARY Background. The ankle joint is a frequent site of injury and bone remodeling, and often requires cartilage repair. Studies have shown that growth factors and bioactive compounds have regenerative properties capable of promoting cartilage restoration. Hyaluronic acid (HA) and orthobiologics like platelet-rich plasma (PRP) and adult stem cells (ASCs) are particularly interesting as therapeutic solutions for ankle … Continued

The Efficacy of Intra-Articular Botulinum-Toxin Injection in Knee Osteoarthritis: A Systematic Review and Meta-analysis

SUMMARY Objective. This investigation aimed to pool and discuss the existed literature on the efficacy and safety of intra-articular injection of Botulinum toxin type A (BTA) for knee osteoarthritis (OA) treatment focusing on different doses and comparing with other injectable agents. Methods. Data sources: a systematic review through PubMed, Scopus, Google Schol­ar and Cochrane Central … Continued

A Single-blind Randomised Trial of Intra-Articular Hyaluronic Acid, Hypertonic Saline, and Physiotherapy in Knee Osteoarthritis

SUMMARY Background. Knee osteoarthritis (OA) is an age-related progressive condition that has resulted in a significant burden worldwide. In this survey, we aimed to compare intra-articular hypertonic saline (HS) and hyaluronic acid (HA) safety and efficacy in the pain and function improvement of patients suffering from knee OA. Eventually, we made a comparison with physical … Continued

Mid Term Effects of a Single Injection versus Three Injections of Hyaluronic Acid in Patients with Rhizarthrosis

SUMMARY Background. To compare the effects of a single intra-articular injection of low molecular weight hyaluronic acid (LMWHA) versus 3 injections of the same LMWHA in patients affected by rhizarthrosis. Methods. 40 patients received ultrasound (US) guided injections of LMW HA: Group A (20 patients) injections with 1 ml HA; Group B (20 patients) once … Continued

Efficacy of a Treatment for Gonarthrosis Based on the Sequential Intra-Articular Injection of Linear and Cross-Linked Hyaluronic Acids

SUMMARY Background. This study evaluates the clinical and biochemical effects of sequential intra-articular (IA) injections of linear (LHA) and cross-linked hyaluronic acid (CLHA) in patients with Gonarthrosis (GA). Methods. Thirty-nine (39) patients (age 64.89 ± 8.83) received first the LHA injection (0.8-1.2 MDa, 32mg/2ml) and after 1 week the CLHA (1.0 MDa and 2.0 MDa, … Continued

Efficacy of ultrasound-guided hyaluronic acid injections in achilles and patellar tendinopathies: a prospective multicentric clinical trial

Background. Achilles and patellar tendinopathies are common causes of chronic pain and functional impairment. Conservative management can be effective, but it is time-consuming and it requires intensive patient compliance. Hyaluronic acid (HA) is a key component of the extracellular matrix and its anti-inflammatory, lubricant and analgesic properties are well documented in osteoarthritis. Growing pre-clinical studies … Continued