The “Fat or Fit Paradox” in Postmenopausal Women: A Cross-Sectional Study on the Association Between Skeletal Muscle Mass, Adiposity, and Muscle Strength

SUMMARY Background. The “Fat or Fit Paradox” denotes an intriguing association between muscle mass and adiposity in older individuals, challenging conventional beliefs on health and fitness. This investigation seeks to elucidate this paradoxical relationship in a cohort of postmenopausal women. Methods. In a cross-sectional study, we assessed the correlation between skeletal muscle mass and body … Continued

Patient Body Mass Index Has No Direct Effect on The Characteristics of Primary Tenocytes Derived from Torn Rotator Cuffs

SUMMARY Background. Obesity is associated with an increased risk of rotator cuff tears and impaired tendon healing after surgery. This study aimed: 1) to investigate the influence of patient body mass index (BMI) on cellular function in tenocytes derived from diseased torn human rotator cuff; 2) to determine if BMI altered the response of tenocytes to tenogenic growth factors. … Continued

The Role of Fibro-Adipogenic Progenitors in Musculoskeletal Disease

SUMMARY Skeletal muscle consists of heterogeneous cell populations that work in concert to support musculoskeletal homeostasis and regeneration in the context of acute injury and chronic disease. In this past decade, the recently discovered sub-population of muscle resident stem cells known as fibro-adipogenic progenitors (FAPs) have been implicated in the pathogenesis and regenerative response to a number of … Continued