Evaluation of the Catabolic and Anabolic Gene Expression Effects and Histology Changes induced by Platelet-Rich Gel Supernatants in Equine Suspensory Ligament Explants Challenged with Lipopolysaccharide

SUMMARY Background. Platelet-rich plasma (PRP) has been used as treatment of ligament desmopathy. However, there is scarce in vitro information about the mechanism of action of leukocyte rich and leukocyte poor PRP related products. The aim of this study was to compare the anti-inflammatory, anabolic and anti-catabolic effects of a leukocyte-concentrate platelet-rich gel supernatant (Lc-PRGS) and a leukocyte-reduced PRGS … Continued