The Role of Fibro-Adipogenic Progenitors in Musculoskeletal Disease

SUMMARY Skeletal muscle consists of heterogeneous cell populations that work in concert to support musculoskeletal homeostasis and regeneration in the context of acute injury and chronic disease. In this past decade, the recently discovered sub-population of muscle resident stem cells known as fibro-adipogenic progenitors (FAPs) have been implicated in the pathogenesis and regenerative response to a number of … Continued

Vascular structures and relationship to intramuscular fat in supraspinatus muscle following tendon detachment and reattachment – an experimental study in rabbits

Background. Supraspinatus (SSP) tendon tear leads to intramuscular fat accumulation and the mechanisms are unknown. We investigated changes in SSP muscle vascularization and association with intramuscular fat following SSP tendon detachment with or without reattachment. Methods. Sixty-six rabbits underwent SSP tendon detachment. In groups of ten, thirty rabbits were sacrificed 4, 8, and 12 weeks … Continued