IS SARM – Selective Androgen Receptor Modulator: A Chance for Therapeutic Approach in Muscle-Wasting Chronic Conditions?

SUMMARY Purpose of review. The purpose of this paper is to review the current concepts regard­ing a new-old pharmacological class, SARM (Selective Androgen Receptor Modula­tor). Especially how SARM can be beneficial in treatment of orthopedic disease. Materials and methods. Androgens (testosterone and dihydrotestosterone (DHT)) are the male sex hormones required for development of the male … Continued

Peripheral Muscle Function and Myoelectric Activity of the Suprahyoid Region in Deglutition of Post-COVID-19 Patients

SUMMARY Objective. To investigate the prevalence of sarcopenia and its association with myoelec­tric activity of the SH region in post-COVID-19 patients, stratified by disease severity and gender. Methods. A cross-sectional study conducted in the post-COVID-19 Outpatient Clinic of a University Hospital. The following outcomes were assessed: swallowing (Dyspha­gia Risk Evaluation Protocol), electromyography of the SH … Continued

Relation Between Components of Oral Health and Sarcopenia in Older Adults: a Narrative Review

SUMMARY Introduction. With the growing population of older adults, a spike in the problems related to aging is expected, with sarcopenia being the foremost. Among the plethora of factors contributing to the development of sarcopenia, oral hypofunction is one among them and there is a growing number of findings on the link between oral health and sarcopenia. However, the … Continued

The Role of Fibro-Adipogenic Progenitors in Musculoskeletal Disease

SUMMARY Skeletal muscle consists of heterogeneous cell populations that work in concert to support musculoskeletal homeostasis and regeneration in the context of acute injury and chronic disease. In this past decade, the recently discovered sub-population of muscle resident stem cells known as fibro-adipogenic progenitors (FAPs) have been implicated in the pathogenesis and regenerative response to a number of … Continued

Electromyostimulation and whole-body vibration effects in elder sarcopenic patients

Background. Sarcopenia is a progressive and generalized loss of the skeletal muscle mass and function associated to aging. Among the different possible practical approaches, the Electromyostimulation (EMS) and the whole-body vibration (WBV) were proposed. The aim of this review is to synthetize the most up-to-date evidence behind the use of this therapeutic approaches. Methods. A … Continued