SUMMARY
Backround. Different suture materials are preferable for the repair of Achilles tendon ruptures. The effect of the sutures on the biological level on a repair scenario is still tentative. The purpose of this study is to show the effects of Vicryl®, Ethibond® and PDS®II on Achilles tendons at mRNA levels.
Methods. 36 Achilles tendons of 18 White New Zealand Rabbit were divided into four groups (n:9). Acute tendon rupture model was created and three groups were repaired with each of the aforementioned sutures (fourth was the control group). At day twelve, mRNA was isolated from each tendon, and expression levels of Collagen (COL) 1A2, COL3A1, Decorin, Matrix Metalloproteinase (MMP) 13 and Interleukin (IL) 1β were measured quantitatively and compared.
Results. Tendons repaired with PDS®II showed high COL1A2, COL3A1 and decorin expression levels (p<0.05). MMP-13 expression was high in Ethibond® group when compared with PDS®II (p<0.05). High IL-1β expression in tendons repaired with Ethibond® was found (p>0.05).
Conclusions. Tendons repaired with PDS®II are found to have superior properties regarding extracellular matrix component synthesis-degradation, and inflammatory cytokine production at mRNA levels when compared to Vicryl® and Ethibond®. These results can be a guide to surgeons regarding suture choice in Achilles tendon repairs.
The Effect of Different Suture Materials on Achilles Tendon Metabolism: A Preliminary in vivo Study of mRNA levels in Rabbits
S. Ergün, A. Alakbarov, A. Mine Yılmaz, B. Karademir, U. Akgün
Original Article, 470-477
Keywords: Achilles, collagen, decorin, MMP-13, mRNA, PDS,
Table of Content: Vol.9 (No.4) 2019 October/December
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The Effect of Different Suture Materials on Achilles Tendon Metabolism: A Preliminary in vivo Study of mRNA levels in Rabbits
S. Ergün, A. Alakbarov, A. Mine Yılmaz, B. Karademir, U. AkgünOriginal Article, 470-477 -
Electrospun Scaffolds in Tendons Regeneration: a review
R. Di Gesù, G. Amato, R. GottardiOriginal Article, 478-493 -
Histological and Biomechanical Evaluation of Biologic Adjuvants in a Murine Tendon-Bone Healing Model
J. Johnson, C. Kia, D. Morikawa, J. Mehl, F.B. Imhoff, A. Otto, L.N. Muench, M.Wolf, J.B. Baldino, X. Xin, M. B. McCarthy, A.D. MazzoccaOriginal Article, 494-505 -
Return to Sport After Patellar Tendon Rupture: a Systematic Review
J. Grondin, P. Menu, T. Garraud, O. Mesland, M. Dauty, A. Fouasson-ChaillouxOriginal Article, 517-524 -
Anti-inflammatory effects of two platelet-rich gel supernatants in an in vitro system of ligament desmitis
C. Castillo-Franz, C. López, M.E. Álvarez, C.E. Giraldo, J.U. CarmonaOriginal Article, 506-516 -
The Effect of Addition of Buffered Dextrose 5% Solution on Pain Occurring During Local Steroid Injection for Treatment of Plantar Fasciitis: A Randomized Controlled Trial
A. Moshrif, M. ElwanOriginal Article, 525-530 -
Patient-Reported Outcome and Healing Biomarkers in Patients Treated by Female versus Male Surgeons – A cohort study on Achilles tendon ruptures
J. Flodin, R. Juthberg, G. Edman, P. AckermannOriginal Article, 531-538 -
Motor imagery training decreases pain on loading in people with moderate Achilles tendinopathy: A preliminary randomised cross-over experiment
J. Debenham, S. Krummenacher, I. Skinner, D. Hince, M. Travers, B. WandOriginal Article, 539-543 -
Quantifying the Dimensions of Achilles Tendon Insertional Area Using Ultrasound Imaging A Validity and Reliability Study
N.H. Alghamdi, M. Killian, B. Aitha, R.T. Pohlig, K. Grävare SilbernagelOriginal Article, 544-551 -
Combined ESWT & RSW Therapy for Achilles Tendinopathy: A Prospective Study
A. Saxena, L. Shou, S. AshrafOriginal Article, 552-561 -
Dynamic Lisfranc Joint Repair Concept: Surgical Technique for a Synthetic Neoligamentplasty
C. Nery, E. Giza, E. Wagner, M. A. Percope de Andrade, T. Soares Baumfeld, M. Pires Prado, D. BaumfeldOriginal Article, 562-570 -
Superior Capsule Reconstruction for Irreparable Rotator Cuff Tear with a Porcine Dermal Graft: Preliminary Results at 2 Years Minimum Follow-up
R. Dukan, A. Bommier, M. A. Rousseau, P. BoyerOriginal Article, 571-578 -
Intermuscular Connections in Anterior Brachium: its Implications in Radial Nerve Entrapment Neuropathy
M. Tonse, M. M. Pai, L.V. Prabhu, B.V. Murlimanju, R. Vadgaonkar, Y.L. RaoOriginal Article, 579-583 -
Treatment of Lateral Epicondylitis with Collagen Injections: a Pilot Study
B. Corrado, G. Mazzuoccolo, L. Liguori, V. A. Chirico, M. Costanzo, I. Bonini, G. Bove, L. CurciOriginal Article, 584-589 -
Short-Term Efficacy and Safety of Betamethasone Valerate 2.25 mg Medicated Plaster in Patients with Chronic Lateral Epicondylitis: Results of a Randomised, Double Blind, Placebo-controlled Study
S. Bernasconi, A. Causero, G. Giaffreda, R. Papalia, G. Caruso, G. Bonanno, F. Sadile, G. Fraschini, M. Fortina, A. Frizziero, N. Chiarelli, V. Salini, U. Tarantino, N. Voglino, A. Castagna, F. A. Grassi, S. Rovati, V. FrangioneOriginal Article, 590-599 -
A diagnostic Approach to Deltoid Muscle Masses
A. Iqbal, E. McLoughlin, A. Patel, A.M. Davies, S.L. James, R. BotchuOriginal Article, 600-605 -
Efficacy of a Treatment for Gonarthrosis Based on the Sequential Intra-Articular Injection of Linear and Cross-Linked Hyaluronic Acids
E. Barbieri, I. Capparucci, F. Mannello, G. Annibalini, S. Contarelli, L. Vallorani, A. M. Gioacchini, D. Ligi, R. Maniscalco, M. Gervasi, T. Tran Dang Xuan, C. Bartolucci, V. Stocchi, P. SestiliOriginal Article, 606-614 -
The Effect of Segmental Stabilization Exercises on Pain, Disability and Static Postural Stability in Patients with Spondylolisthesis: A Double Blinded Pilot Randomized Controlled Trial
R. Choopani, F. Ghaderi, Z. Salahzadeh, H. Adigozali, H.N. Sivaki, E.M. Majd, M.R. Azghani, A. Soltani, M.A. JafarabadiOriginal Article, 615-626 -
Matside Medical Aid during Judo Competition in Japan
A. Ikumi, N. Sakuyama, N. Takatori, T. Kamitani, S. Miyazaki, Y. Nimura, N. Maffulli, N. G. Malliaropoulos, S. NagahiroOriginal Article, 627-634 -
Synergistic Effect of Physical Therapy Plus Pharmacological Therapy with Eperisone in Tension-Type Cervicalgia
C. Asaro, D. Scaturro, S. Tomasello, L.G. Tumminelli, G. Letizia MauroOriginal Article, 635-641