SUMMARY
Skeletal muscle consists of heterogeneous cell populations that work in concert to support musculoskeletal homeostasis and regeneration in the context of acute injury and chronic disease. In this past decade, the recently discovered sub-population of muscle resident stem cells known as fibro-adipogenic progenitors (FAPs) have been implicated in the pathogenesis and regenerative response to a number of musculoskeletal conditions ranging from acute muscle injury to neurodegenerative disease, muscular dystrophy, rotator cuff tears, sarcopenia and heterotopic ossification. The purpose of this literature review is to synthesize a complete collection of basic, translational, and clinical science evidence implicating FAPs in the pathogenesis and regenerative response to acute and chronic musculoskeletal diseases. This study is an extensive literature review of papers recently published on FAPs in the development of acute and chronic musculoskeletal degeneration, and their potential role in therapeutic regeneration of these injuries. In this review, we highlight the multipotency of FAPs on a molecular level and review their role in the pathogenesis of acute, chronic, and degenerative musculoskeletal disorders with implications for the development of future novel therapeutic interventions.
The Role of Fibro-Adipogenic Progenitors in Musculoskeletal Disease
G. Kaur, M. R. Davies, X. Liu, B. T. Feeley
Review, 201-214
Keywords: acute muscle injury, amyotrophic lateral sclerosis, cardiac fibrosis, chronic kidney disease, chronic obstructive pulmonary disease, fibro-adipogenic progenitors, heterotopic ossification, muscular dystrophy, neurodegenerative disease, obesity, rotator cuff tear, sarcopenia, spinal muscle atrophy,
Table of Content: Vol. 11 (No.2) 2021 April/June
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The Role of Fibro-Adipogenic Progenitors in Musculoskeletal Disease
G. Kaur, M. R. Davies, X. Liu, B. T. FeeleyReview, 201-214 -
Effects of Traditional Srichiangmai dance on Balance and Mobility in the Elderly
M. Buransri, Y. PhanphengOriginal Article, 215-222 -
Natural History of Patients with Acute Proximal Biceps Tendon Rupture
D. P. Axibal, N. C. Yeatts, A. J. Rao, K. R. Muña, I. S. Hong, P. M. Connor, J. E. Fleischli, D. P. Piasecki, B. M. Saltzman, N. HamidOriginal Article, 223-230 -
Dominant vs Nondominant Arm in Surgical Repair of Distal Biceps Tendon Rupture. A Case-Control Series of Isotonic Muscle Strength Evaluation
F. Calderazzi, F. Addevico, C. Galavotti, A. Nosenzo, M. Menozzi, A. Garzia, C. CostantinoOriginal Article, 231-239 -
Comparison between Conservative and Surgical Treatment in Proximal Humeral Fractures. A Prospective Randomized Study with 5-Years Follow-Up
M. Guzzini, R. M. Lanzetti, G. Princi, M. Spoliti, M. C. Moretti, G. Koverech, A. P. Vadalà, D. Mazza, F. Cannari, D. Topa, A. FerrettiOriginal Article, 240-245 -
Can Supraspinatus Tears Contribute to Acquired Subcoracoid Impingement? A Radiological Study of Anterosuperior Cuff Tears
M. J. Leite, A. R. Pinho, M. C. Sá, M. R. Silva, J. M. Almeida, A. N. Sousa, J. M. TorresReview, 246-250 -
The Effectiveness of Trigger Point Injection Plus Kinesio Taping in Myofascial Pain Syndrome: a Randomized, Sham-Controlled Clinical Trial
E. YılmazOriginal Article, 251-258 -
Cross-Cultural Adaptation and Measurement Properties of the Brazilian Portuguese Version of Two Scales Which Measure Function and Disability in People with Achilles Tendinopathy
Y. A. Bandeira Murakawa, S. F. Chaves Coêlho Ferreira, M. L. Azevedo Tavares, M. Almeida Bezerra, R. Ribeiro de OliveiraOriginal Article, 259-264 -
TGF-ß1 Expression in Contractured Achilles Tendon among Diabetic Foot Patients: a Semi-Quantitative Study
R. A. Primadhi, H. Gunawan, S. Rachmayati, H. N. RasyidOriginal Article, 265-272 -
Anterior Tibial Tendon Transfer for Treatment of Recurrent Congenital Clubfoot Initially Treated According to Ponseti Method. Update and Systematic Review Of Literature
V. De Luna, A. Caterini, G. Gorgolini, M. Marsiolo, F. De Maio, P. FarsettiReview, 273-280 -
An adaptive Model of Achilles Tendon Mechanical Properties during Adolescence: Effect of Sex
G. Chalatzoglidis, A. J. Blazevich, F. ArabatziOriginal Article, 281-291 -
Identifying Differences in Elastographic Properties of Calf Muscles and Tendons Across Subsets of Tennis Players
C. D. Sacks, R. A. Gallo, L. Kong, D. H. CortesOriginal Article, 292-300 -
Ligamentum Teres and its Analog in the Hip Endoprosthesis – Necessary or Superfluous? A Systematic Review
S. V. Arkhipov, D. V. SkvortsovReview, 301-310 -
Estimating the Dynamic Ratio of the Lateral/Medial Hamstrings. A Case Control Study
N. Malliaropoulos, G. Bikos, D. Pyne, G. Kakavas, N. Maffulli, P. TsaklisOriginal Article, 311-317 -
A 90 Minute Soccer Match Induces Eccentric Hamstring Muscles Fatigue
G. Kakavas, N. Malliaropoulos, T. Gabbett, M. Mitrotasios, N. Van Dyk, G. Bikos, N. MaffulliOriginal Article, 318-323 -
Quick Recovery and No Arthrofibrosis in Acute Anterior Cruciate Ligament Reconstruction: a Prospective Trial of Early versus Delayed Reconstruction
E. Monaco, F. Iannotti, A. Carrozzo, A. Annibaldi, F. Marzilli, M. Nurzia , P. F. Indelli, A. FerrettiOriginal Article, 324-332 -
High Frequency Transcutaneous Electrical Nerve Stimulation in the Immediate Postoperative Period of Anterior Cruciate Ligament Reconstruction and Its Effects on Drug Costs During Hospitalization
M. B. Dohnert, N. de Oliveira Cardoso Novaski, J. Ribeiro Deves, A. Rennan de Oliveira Soares, M. Medeiros da Silveira, J. Victor Euzébio dos Santos, P. A. Kuplich, R. Boff DaitxOriginal Article, 333-339 -
Evaluation of Antifibrinolytic Use in Anterior Cruciate Ligament Arthroscopic Reconstruction. A Prospective Clinical Trial
V. La Banca, J. G. Suzuki Leal Roque, T. Protta, M. Schmidt NavarroOriginal Article, 340-343 -
Low Back Pain and Associated Factors among Italian Equestrian Athletes: a Cross-Sectional Study
M. Ferrante, F. Bonetti, F. M. Quattrini, M. Mezzetti, S. DemarieOriginal Article, 344-352 -
Most Impacting Injuries in Football: a Possible Association?
M. Glaied, G. N. Bisciotti, A. Bisciotti, A. Bisciotti, C. EiraleCase Report, 353-359 -
The Relationship between Active and Passive Flexibility of the Knee Flexors
P. Niewiadomy, K. Szuścik-Niewiadomy, M. Kochan, M. T. KuszewskiOriginal Article, 360-366