SUMMARY
Background. Dystrophic skeletal muscle undergoes fast degeneration and therapeutic exercise is controversial in this condition. The aim of this study was investigate the effects of a low-intensity training protocol on muscle fibrosis and function of the mdx model.
Methods. Mdx male animals with 8 weeks of age were (T0; n=8) underwent a protocol of eight weeks at a horizontal treadmill (9 m/min, 3x/week, 30 min/day). Mdx animals were randomly allocated at the Trained group (mdx-T, n=8) or sedentary (mdx-NT, n=8). In vivo functional measurements of strength and performance, immunolocalization of TGF-β1 and histomorphometry of intramuscular collagen fibers were assessed over time of protocol (T0, T4, T8) on Tibial Anterior (TA) and Soleus (SOL).
Results. Strength decreased after 4 weeks of training (T4) and was regained at T8 at mdx-T. The percentage of intramuscular collagen fibers area decreased at SOL muscle of mdx-T at T4 when compared to T0 (p=0,025) and TA of mdx-T had a lesser area at T8 when compared to TA of mdx-NT group (p=0,002). TGF-β1 was observed at the sarcoplasm of TA and SOL muscles of mdx-NT group, with an age-dependent change.
Conclusions. Treadmill low-intensity training provoked dystrophic skeletal muscle adaptation of fibrosis and maintained grip strength of the mdx model.
Treadmill Low-Intensity Training Mediates Fibrosis and Maintains the Function of Dystrophic Muscle: Understanding the Effects Over Time
A. Ferreira Lemes de Morais, P. Avelino Ferreira Pinto, A. Nobre Evangelista, A. P. Santos, A. S. Dias Machado, T. Peixoto Gaiad
Original Article, 724-733
Keywords: Duchenne muscular dystrophy; mdx model; low-intensity training; treadmill; fibrosis; TGF-β1,
Table of Content: Vol. 10 (No.4) 2020 October/December
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